Hydrogen Excess Drives Metabolic Reprogramming and Viral Dynamics in Syngas-Converting Microbiomes

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  • November 18, 2025

Authors: Gabriele Ghiotto, Luca Francescato, Maria Agustina Biancalani, Laura Treu, Stefano Campanaro

This study reveals that excess hydrogen triggers profound metabolic and viral remodeling in thermophilic anaerobic microbiomes used for syngas methanation. Transcriptional downregulation of methanogenesis genes in Methanothermobacter thermautotrophicus, alongside upregulation of CRISPR-Cas defense systems, was observed. These findings shed light on microbial instability mechanisms relevant to Power-to-Gas technologies.

Read the full article: https://www.sciencedirect.com/science/article/pii/S2666498425001152

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